Autoimmune statin-induced myopathy: a case report

被引：9
作者：
Young, Jonathan B. [1 ]
Ghobrial, Ibrahim I. [1 ]
机构：
[1] UPMC McKeesport Hosp, Dept Med, Mckeesport, PA USA
来源：
JOURNAL OF COMMUNITY HOSPITAL INTERNAL MEDICINE PERSPECTIVES | 2015年 / 5卷 / 04期
关键词：
statin; necrotizing myopathy; autoimmune; 3-hydroxy-3-methylglutaryl-coenzyme A reductase; antibody;
D O I：
10.3402/jchimp.v5.28374
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A 58-year-old woman with a history of statin use presented with a 4-month history of progressive weakness of both shoulders and thighs. Laboratory and electromyography testing confirmed the presence of generalized proximal myopathy and ruled out connective tissue disease, malignancy, or active viral infection. Muscle biopsy was consistent with necrotizing autoimmune myopathy.
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页数：4
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共 12 条
  • [1] A Novel Autoantibody Recognizing 200-kd and 100-kd Proteins Is Associated With an Immune-Mediated Necrotizing Myopathy
    Christopher-Stine, Lisa
    Casciola-Rosen, Livia A.
    Hong, Grace
    Chung, Tae
    Corse, Andrea M.
    Mammen, Andrew L.
    [J]. ARTHRITIS AND RHEUMATISM, 2010, 62 (09): : 2757 - 2766
  • [2] A historical perspective on the discovery of statins
    Endo, Akira
    [J]. PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES, 2010, 86 (05): : 484 - 493
  • [3] Statin-associated necrotizing autoimmune myopathy
    Fernandes, Georgea Hermogenes
    Zanoteli, Edmar
    Shinjo, Samuel Katsuyuki
    [J]. MODERN RHEUMATOLOGY, 2014, 24 (05) : 862 - 864
  • [4] IMMUNE-MEDIATED NECROTIZING MYOPATHY ASSOCIATED WITH STATINS
    Grable-Esposito, Phyllis
    Katzberg, Hans D.
    Greenberg, Steven A.
    Srinivasan, Jayashri
    Katz, Jonathan
    Amato, Anthony A.
    [J]. MUSCLE & NERVE, 2010, 41 (02) : 185 - 190
  • [5] Ioannidis JPA, 2013, JAMA-J AM MED ASSOC, V94305, pE1
  • [6] Necrotizing autoimmune myopathy
    Liang, Christina
    Needham, Merrilee
    [J]. CURRENT OPINION IN RHEUMATOLOGY, 2011, 23 (06) : 612 - 619
  • [7] Autoantibodies Against 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase in Patients With Statin-Associated Autoimmune Myopathy
    Mammen, Andrew L.
    Chung, Tae
    Christopher-Stine, Lisa
    Rosen, Paul
    Rosen, Antony
    Doering, Kimberly R.
    Casciola-Rosen, Livia A.
    [J]. ARTHRITIS AND RHEUMATISM, 2011, 63 (03): : 713 - 721
  • [8] The spectrum of statin myopathy
    Mohassel, Payam
    Mammen, Andrew L.
    [J]. CURRENT OPINION IN RHEUMATOLOGY, 2013, 25 (06) : 747 - 752
  • [9] Progressive myopathy with up-regulation of MHC-I associated with statin therapy
    Needham, Merrilee
    Fabian, Victoria
    Knezevic, Wally
    Panegyres, Peter
    Zilko, Paul
    Mastaglia, Frank L.
    [J]. NEUROMUSCULAR DISORDERS, 2007, 17 (02) : 194 - 200
  • [10] Statins as a possible cause of inflammatory and necrotizing myopathies
    Padala, Santosh
    Thompson, Paul D.
    [J]. ATHEROSCLEROSIS, 2012, 222 (01) : 15 - 21
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