EXTRATHYMIC POSITIVE SELECTION OF GAMMA-DELTA T-CELLS - V-GAMMA-4J-GAMMA-1 REARRANGEMENTS WITH GXYS JUNCTIONS

被引：0
作者：
SIM, GK
AUGUSTIN, A
机构：
[1] NATL JEWISH CTR IMMUNOL & RESP MED,DEPT MED,1400 JACKSON ST,DENVER,CO 80206
[2] BASEL INST IMMUNOL,CH-4005 BASEL,SWITZERLAND
[3] UNIV COLORADO,HLTH SCI CTR,DEPT MICROBIOL & IMMUNOL,DENVER,CO 80262
来源：
JOURNAL OF IMMUNOLOGY | 1991年 / 146卷 / 07期
关键词：
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Neither function nor Ag recognition properties of gamma-delta T cells are well understood yet. A TCR gamma-chain family, characterized by distinct N region sequences that converge in coding for a "GxYS" VJ junctional sequence, appears late in ontogeny among highly diversified V-gamma-4J-gamma-1C-gamma-1 chains of C57BL/6 and BALB/c mice. The glycine and serine codons are of germ-line V-gamma-4 and J-gamma-1 origin, respectively, whereas the N region consists of a variable amino acid residue x, followed by an invariant tyrosine Y. The high expression of V-gamma-4 xYJ-gamma-1C-gamma-1 in the lung of BALB/c mice compared to that of C57BL/6 is apparently due to a novel pattern of strain-dependent positive selection which, unlike for alpha-beta TCR, operates extrathymically. This type of selection seems to be determined by strain specific polymorphic ligands encoded outside of the classical H-2 region.
引用
收藏
页码：2439 / 2445
页数：7
相关论文
共 26 条
[1]   LIMITED DIVERSITY OF GAMMA-DELTA-ANTIGEN RECEPTOR GENES OF THY-1+ DENDRITIC EPIDERMAL-CELLS [J].
ASARNOW, DM ;
KUZIEL, WA ;
BONYHADI, M ;
TIGELAAR, RE ;
TUCKER, PW ;
ALLISON, JP .
CELL, 1988, 55 (05) :837-847
[2]   DISTINCT ANTIGEN RECEPTOR REPERTOIRES OF 2 CLASSES OF MURINE EPITHELIUM-ASSOCIATED T-CELLS [J].
ASARNOW, DM ;
GOODMAN, T ;
LEFRANCOIS, L ;
ALLISON, JP .
NATURE, 1989, 341 (6237) :60-62
[3]   RESIDENT PULMONARY LYMPHOCYTES EXPRESSING THE GAMMA-DELTA T-CELL RECEPTOR [J].
AUGUSTIN, A ;
KUBO, RT ;
SIM, GK .
NATURE, 1989, 340 (6230) :239-241
[4]   ANTIGEN MHC-SPECIFIC T-CELLS ARE PREFERENTIALLY EXPORTED FROM THE THYMUS IN THE PRESENCE OF THEIR MHC LIGAND [J].
BERG, LJ ;
PULLEN, AM ;
FAZEKAS DE ST GROTH, B ;
MATHIS, D ;
BENOIST, C ;
DAVIS, MM .
CELL, 1989, 58 (06) :1035-1046
[5]   THE EFFECTS OF MHC GENE DOSAGE AND ALLELIC VARIATION ON T-CELL RECEPTOR SELECTION [J].
BERG, LJ ;
FRANK, GD ;
DAVIS, MM .
CELL, 1990, 60 (06) :1043-1053
[6]   INFLUENCE OF THE MAJOR HISTOCOMPATIBILITY COMPLEX ON POSITIVE THYMIC SELECTION OF V-BETA-17A+ T-CELLS [J].
BLACKMAN, MA ;
MARRACK, P ;
KAPPLER, J .
SCIENCE, 1989, 244 (4901) :214-217
[7]   TRANSGENIC MICE DEMONSTRATE THAT EPITHELIAL HOMING OF GAMMA-DELTA-T-CELLS IS DETERMINED BY CELL LINEAGES INDEPENDENT OF T-CELL RECEPTOR SPECIFICITY [J].
BONNEVILLE, M ;
ITOHARA, S ;
KRECKO, EG ;
MOMBAERTS, P ;
ISHIDA, I ;
KATSUKI, M ;
BERNS, A ;
FARR, AG ;
JANEWAY, CA ;
TONEGAWA, S .
JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 171 (04) :1015-1026
[8]  
CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2
[9]   T-CELL FUNCTION AND EXPRESSION ARE DRAMATICALLY ALTERED IN T-CELL RECEPTOR V-GAMMA-1.1J-GAMMA-4C-GAMMA-4 TRANSGENIC MICE [J].
FERRICK, DA ;
SAMBHARA, SR ;
BALLHAUSEN, W ;
IWAMOTO, A ;
PIRCHER, H ;
WALKER, CL ;
YOKOYAMA, WM ;
MILLER, RG ;
MAK, TW .
CELL, 1989, 57 (03) :483-492
[10]   EXPRESSION OF THE GAMMA-DELTA-T-CELL RECEPTOR ON INTESTINAL CD8+ INTRAEPITHELIAL LYMPHOCYTES [J].
GOODMAN, T ;
LEFRANCOIS, L .
NATURE, 1988, 333 (6176) :855-858
123