INFLUENCE OF SOMATOSTATIN AND EPIDERMAL GROWTH-FACTOR (EGF) ON THE PROLIFERATION OF THYROID FOLLICULAR CELLS IN ORGAN-CULTURE

被引：7

作者：

ZEREKMELEN, G ^{[1
]}

LEWINSKI, A ^{[1
]}

SZKUDLINSKI, M ^{[1
]}

机构：

[1] MED ACAD LODZ,DEPT EXPTL ENDOCRINOL & HORMONE DIAGNOST,THYROL LAB,DR STERLING ST 3,PL-91425 LODZ,POLAND

来源：

REGULATORY PEPTIDES | 1990年 / 28卷 / 03期

关键词：

Epidermal growth factor; Organ culture; Proliferation; Somatostatin; Thyroid;

D O I：

10.1016/0167-0115(90)90027-T

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of the present study has been to examine the effects of various concentrations of somatostatin (SS), epidermal growth factor (EGF), as well as of interactions among SS, EGF and thyrotropin (TSH) in their influence upon the mitotic activity of thyroid follicular cells (TFC) in organ culture. The stathmokinetic method was employed. It was shown that: (1) SS, at the concentration of 10-7 M, suppressed the mitogenic effect of TSH, as well as of TSH and EGF employed together, on TFC; (2) EGF, at the concentration of 10 and 100 ng/ml, increased the mean mitotic activity rate of TFC; (3) TSH and EGF revealed and additive action on TFC proliferation. The obtained results evidently suggest an antiproliferative effect of SS and mitogenic action of EGF on TFC in organ culture. © 1990.

引用

页码：293 / 300

页数：8

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