G0 IS A MAJOR GROWTH CONE PROTEIN SUBJECT TO REGULATION BY GAP-43

被引：418
作者：
STRITTMATTER, SM
VALENZUELA, D
KENNEDY, TE
NEER, EJ
FISHMAN, MC
机构：
[1] MASSACHUSETTS GEN HOSP, DEV BIOL LAB, BOSTON, MA 02114 USA
[2] HARVARD UNIV, SCH MED, HOWARD HUGHES MED INST, DEPT NEUROL, BOSTON, MA 02115 USA
[3] HARVARD UNIV, SCH MED, HOWARD HUGHES MED INST, DEPT MED, BOSTON, MA 02115 USA
[4] COLUMBIA UNIV, CTR NEUROBIOL & BEHAV, NEW YORK, NY 10032 USA
[5] BRIGHAM & WOMENS HOSP, DIV CARDIOVASC, BOSTON, MA 02115 USA
来源：
NATURE | 1990年 / 344卷 / 6269期
关键词：
D O I：
10.1038/344836a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
G0, a GTP-binding protein that transduces information from transmembrane receptors, has been found to be a major component of the neuronal growth cone membrane. GAP-43, an intracellular growth cone protein closely associated with neuronal growth, stimulates GTP-γ-S binding to G0. It does so through an amino-terminal domain homologous to G-linked transmembrane receptors. Thus, G0in the growth cone may be regulated by intracellular as well as extracellular signals. © 1990 Nature Publishing Group.
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页码：836 / 841
页数：6
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