COMPARATIVE GENOMIC HYBRIDIZATION ANALYSIS OF HUMAN SARCOMAS .2. IDENTIFICATION OF NOVEL AMPLICONS AT 6P AND 17P IN OSTEOSARCOMAS

被引：132

作者：

FORUS, A ^{[1
]}

WEGHUIS, DO ^{[1
]}

SMEETS, D ^{[1
]}

FODSTAD, O ^{[1
]}

MYKLEBOST, O ^{[1
]}

VANKESSEL, AG ^{[1
]}

机构：

[1] UNIV NIJMEGEN HOSP, DEPT HUMAN GENET, 6500 HB NIJMEGEN, NETHERLANDS

来源：

GENES CHROMOSOMES & CANCER | 1995年 / 14卷 / 01期

关键词：

D O I：

10.1002/gcc.2870140104

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Using comparative genomic hybridization (CGH), we have identified and mapped regions of DNA amplification in primary and metastatic osteosarcomas. Samples were obtained from four patients and ten independent xenografts. Sixty-four percent of the tumors showed increased DNA-sequence copy numbers, affecting 23 different chromosomal sites. Most of these regions were not previously associated with the development and/or progression of these tumors. Amplicons originating from 1q21-q23, 6p, 8q23-qter, and 17p11-p12 were observed most frequently. The 6p and 17p11-p12 amplicons seem to be specific for osteosarcomas, indicating that these regions may harbor genes relevant for the development of these tumors. (C) 1995 Wiley-Liss, Inc.

引用

页码：15 / 21

页数：7

共 34 条

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