DORSAL STRIATAL MECHANISMS INVOLVED IN THE DOPAMINE D-2 RECEPTOR-MEDIATED POTENTIATION OF APOMORPHINE-INDUCED JAW MOVEMENTS

被引:0
作者
DEBELTRAN, KK [1 ]
KOSHIKAWA, N [1 ]
MIWA, Y [1 ]
KOBAYASHI, M [1 ]
机构
[1] NIHON UNIV,SCH DENT,DEPT PHARMACOL,CHIYODA KU,TOKYO 101,JAPAN
关键词
JAW MOVEMENT; STRIATUM; DORSAL; DOPAMINE D-1/D-2 RECEPTOR INTERACTION; DOPAMINERGIC/CHOLINERGIC INTERACTION; (RAT);
D O I
10.1016/0014-2999(94)90580-0
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The role of dorsal striatal mechanisms in the regulation of apomorphine-induced jaw movements was studied. Jaw movements induced by apomorphine (0.2 mg/kg i.v.) were potentiated by quinpirole (10 mu g/0.2 mu l) injected into the dorsal part of the striatum 10 min before apomorphine. Quinpirole injection into the ventral part of the striatum did not affect the effects of apomorphine. The quinpirole-induced potentiation in the dorsal striatum was prevented by l-sulpiride (25 ng), nemonapride (1 mu g), SCH23390 (1 mu g) or methylscopolamine (1 mu g), but not muscimol (50 ng), co-administered with quinpirole. Injection of these drugs alone 10 min before apomorphine failed to alter the effects of apomorphine. I-Sulpiride (25 ng) injected into the dorsal striatum 60 min before apomorphine increased the frequency of jaw movements induced by apomorphine (0.2 mg/kg). The l-sulpiride-induced potentiation was prevented by methylscopolamine (0.1 mu g) or l-sulpiride (25 ng) injected into the dorsal striatum 10 min before apomorphine; we had already found that this potentiation was also blocked by SCH23390. It is suggested that a synergistic dopamine D-1/D-2 receptor interaction underlies both the quick-onset potentiation by quinpirole and the delayed-onset potentiation by l-sulpiride.
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页码:99 / 104
页数:6
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