THE ADJUVANT EFFECT OF INTERLEUKIN-12 IN A VACCINE AGAINST LEISHMANIA-MAJOR

被引：657

作者：

AFONSO, LCC

SCHARTON, TM

VIEIRA, LQ

WYSOCKA, M

TRINCHIERI, G

SCOTT, P

机构：

[1] UNIV PENN,SCH VET MED,DEPT PATHOBIOL,PHILADELPHIA,PA 19104

[2] WISTAR INST ANAT & BIOL,PHILADELPHIA,PA 19104

来源：

SCIENCE | 1994年 / 263卷 / 5144期

关键词：

D O I：

10.1126/science.7904381

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Protection induced by vaccination depends on the capacity of the vaccine to elicit an appropriate immune response. In leishmaniasis, protection requires leishmanial-specific CD4+ T helper (T(H)) cells. Vaccination of BAL-B/c mice with leishmanial antigens and interleukin-12 (IL-12) promoted the development of leishmanial-specific CD4+ T(H)1 cells These mice were resistant to subsequent infection with Leishmania major. Thus, IL-12 is an effective adjuvant for the initiation of protective cell-mediated immunity against leishmaniasis and may be an important component in other vaccines that need tc induce cell-mediated immunity.

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页码：235 / 237

页数：3

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