ENHANCEMENT OF PHORBOL ESTER-INDUCED PRODUCTION OF TUMOR-NECROSIS-FACTOR-ALPHA BY 2,6-DIMETHYLPHENYLPHTHALIMIDE

被引：0
作者：
SHIBATA, Y
SASAKI, K
NISHIMURA, K
HASHIMOTO, Y
IWASAKI, S
机构：
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 1994年 / 17卷 / 11期
关键词：
2; 6-DIMETHYLPHENYLPHTHALIMIDE; TUMOR NECROSIS FACTOR-ALPHA; STRUCTURE-ACTIVITY RELATIONSHIP;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effect of phenyl- and benzylphthalimide analogs on tumor necrosis factor (TNF)-alpha production by a human leukemia cell line, HL-60, stimulated with 12-O-tetradecanoylphorbol-13-acetate (TPA) was investigated. Though non-substituted phenyl- and benzylphthalimide had no effect on TNF-alpha production after TPA-induction, introduction of methyl group(s) onto the phenyl group resulted in the appearance of potent enhancing activity on TNF-alpha production.
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页码：1532 / 1534
页数：3
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