SYNTHESIS OF AMINO-ACID DERIVATIVES OF NEAMINE AND 2-DEOXYSTREPTAMINE TO BE USED AS MUTASYNTHONS

被引：19

作者：

GEORGIADIS, MP ^{[1
]}

CONSTANTINOUKOKOTOU, V ^{[1
]}

KOKOTOS, G ^{[1
]}

机构：

[1] UNIV ATHENS,DEPT CHEM,ATHENS,GREECE

来源：

JOURNAL OF CARBOHYDRATE CHEMISTRY | 1991年 / 10卷 / 05期

关键词：

D O I：

10.1080/07328309108543947

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

6'-N derivatives of neamine with alanine, phenylalanine and lysine were synthesized either using an active esters method in one step under controlled conditions, or using a mixed anhydride method after blocking every functional group of neamine and leaving the 6'-amino group free to react. Similarly N,N'-diamino acid and monoamino acid derivatives of 2-deoxystreptamine were synthesized.

引用

收藏

页码：739 / 748

页数：10

相关论文

共 19 条

[1] N-HYDROXYSUCCINIMIDE ESTERS IN PEPTIDE SYNTHESIS [J].

ANDERSON, GW ;

ZIMMERMAN, JE ;

CALLAHAN, FM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1963, 85 (19) :3039-&

[2] USE OF ESTERS OF N-HYDROXYSUCCINIMIDE IN PEPTIDE SYNTHESIS [J].

ANDERSON, GW ;

CALLAHAN, FM ;

ZIMMERMAN, JE .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1964, 86 (09) :1839-+

[3] THE IDENTITY OF NEOMYCIN-A, NEAMINE AND THE METHANOLYSIS PRODUCT OF NEOMYCIN-B AND NEOMYCIN-C3 [J].

DUTCHER, JD ;

DONIN, MN .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1952, 74 (13) :3420-3422

[4]

DYER JR, 1954, THESIS U ILLINOIS

[5]

GERO S, 1983, CHEM BIOTECHNOLOGY B, P79

[6] C-13 NUCLEAR MAGNETIC-RESONANCE SPECTRAL ANALYSIS OF TOBRAMYCIN AND RELATED ANTIBIOTICS [J].

KOCH, KF ;

RHOADES, JA ;

HAGAMAN, EW ;

WENKERT, E .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1974, 96 (10) :3300-3305

[7] ON OPTICAL PURITY OF PEPTIDE ACTIVE ESTERS PREPARED BY N,N'-DICYCLOHEXYLCARBODIIMIDE AND COMPLEXES OF N,N' -DICYCLOHEXYLCARBODIIMIDE-PENTACHLOROPHENOL AND N,N'-DICYCLOHEXYLCARBODIIMIDE-PENTAFLUOROPHENOL [J].

KOVACS, J ;

KISFALUDY, L ;

CEPRINI, MQ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1967, 89 (01) :183-+

[8] SEMI-SYNTHETIC AMINOGLYCOSIDE ANTIBACTERIALS .10. SYNTHESIS OF NOVEL 1-N-AMINOALKOXYCARBONYL AND 1-N-AMINOALKYLCARBOXAMIDO DERIVATIVES OF SISOMICIN, GENTAMICIN-B, GENTAMICIN-C1A, AND KANAMYCIN-A [J].

MALLAMS, AK ;

MORTON, JB ;

REICHERT, P .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1981, (08) :2186-2208

[9]

Meienhofer J., 1979, PEPTIDES ANAL SYNTHE, V1, P263

[10]

NAGABHUSHAN TL, 1975, TETRAHEDRON LETT, P747