THE EFFECT OF PHYSICAL ACTIVITY AND ATORVASTATIN ACTION ON LIPID PROFILE OF SEDENTARY AND NON SEDENTARY ALCOHOLIC MYOCARDIAL INFARCTION PATIENTS

BACKGROUND: World Health Organization estimated 2 million deaths each year because of cardio vascular disease. The sedentary life style and increased lipid levels, obesity, alcohol, smoking and modernization of life styles contribute as risk factors for myocardial infarction. Framingham Study reviewed relationship between ischemic heart disease and physical activity. 1 Lack of physical activity cause more damage to the body. Manson reported 60%(2) of americans belonging to sedentary group with high risk of cardio vascular diseases. METHODS: The study is conducted for 8 weeks. The data for study was collected from 70 patients of known myocardial infarction with alcoholism and hyperlipidemias, some were sedentary and some were non sedentary who attended cardiology OP of King George Hospital, Visakhapatnam. RESULTS: Both the groups were given Tab. Atorvastatin 20mg/day, themean age group of the Patients is between 40 to 70 years andweight 6085 kgs. The lipid levels are high as the age is increasing and the incidence of disease is high among age 56-60 years. As they are sedentary, least incidence is seen among the age group 40-45 years. The averageamount of alcohol consumed by these people is 80-150 ml/day. The lipid profiles are checked thrice in the entire study. From group A the mean total cholesterol is 217.867mg/dl, the mean triglycerides is 275.466mg/dl, the mean HDL is 40.96mg/dl, the mean LDL is 40.96mg/dl, and from group B the mean Total Cholesrerol is 190.033mg/dl, the mean triglycerides is 158.533mg/dl, the mean LDL is 110.233mg/dl, the mean HDL is 47.66mg/dl. The t-value and p-values are more significant and they showed reduction of LDL and triglyceride levels in nonsedentary life style people than sedentary lifestyle people. CONCLUSION: It is observed that the non sedentary hyperlipidemic alcoholic post MI patients who are administered with Atorvastatin has good therapeutic effect than the sedentary hyperlipidemic alcoholic post MI patients who are administered with Atorvastatin, there was a minimal increase of HDL levels. Patients having physical activity have a synergistic effect withatorvastatin drug to decrease the risk of cardio vascular diseases. This study suggests that there is an immense scope of an improvement in the risk factors related diseases by modifying our life style.