INTERFERON-GAMMA REGULATION OF MAJOR HISTOCOMPATIBILITY CLASS-I GENE-EXPRESSION IN RAT-CELLS CONTAINING THE ADENOVIRUS-12 E1A ONCOGENE

被引：7

作者：

ACKRILL, AM ^{[1
]}

BLAIR, GE ^{[1
]}

机构：

[1] UNIV LEEDS, DEPT BIOCHEM, LEEDS LS2 9JT, W YORKSHIRE, ENGLAND

来源：

VIROLOGY | 1990年 / 174卷 / 01期

关键词：

D O I：

10.1016/0042-6822(90)90084-5

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Interferon-γ (IFNγ) treatment of cells expressing the Ad12 ElA oncogene results in an increase in MHC class I antigen expression. The effect of IFNγ upon both the steady-state level of class I mRNA and the in vitro rate of initiation of transcription of class I genes was studied in a rat cell line containing the Ad12 E1 A gene. Results obtained showed a marked increase in steady-state level of cytoplasmic class I mRNA; however, a concomitant increase in the rate of transcription of class I genes was not observed. In contrast IFNy was shown to markedly increase the rate of transcription of class I genes in primary baby rat kidney cells. © 1990.

引用

页码：325 / 328

页数：4

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