MOUSE LEUKEMIA VIRUS ACTIVATION BY CHEMICAL CARCINOGENS

被引：106

作者：

IGEL, HJ

HUEBNER, RJ

TURNER, HC

KOTIN, P

FALK, HL

机构：

[1] Children's Hospital, Akron

[2] National Cancer Institute, Bethesda

[3] National Institute of Environmental Health Sciences, Research Triangle Park, NC

来源：

SCIENCE | 1969年 / 166卷 / 3913期

关键词：

D O I：

10.1126/science.166.3913.1624

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The induction of lymphomas in C57BL mice by methylcholanthrene, urethan, or diethylnitrosamine was accompanied by the development of murine leukemia viral antigen in most of the lymphoid tumors. The cell-free transmission of lymphomas induced by methylcholanthrene and the development of antibody to murine leukemia virus prior to the detection of overt lymphoma in these mice suggest that unmasking of a latent leuikemia viruis is an indigenous actuating cause of the lymphomas.

引用

页码：1624 / &

共 17 条

[1]

CLAPP NK, 1969, P AM ASSOC CANC RES, V10, P14

[2] MECHANISM OF RADIATION ACTION IN LEUKAEMOGENESIS - ISOLATION OF A LEUKAEMOGENIC FILTRABLE AGENT FROM TISSUES OF IRRADIATED AND NORMAL C57BL MICE [J].