AN ALPHA-SATELLITE DNA POLYMORPHISM SPECIFIC FOR THE CENTROMERIC REGION OF CHROMOSOME-13

被引：21
|
作者：
WARREN, AC
BOWCOCK, AM
FARRER, LA
ANTONARAKIS, SE
机构：
[1] JOHNS HOPKINS UNIV,SCH MED,DEPT PEDIAT,BALTIMORE,MD 21205
[2] JOHNS HOPKINS UNIV,SCH MED,CTR MED GENET,BALTIMORE,MD 21205
[3] STANFORD UNIV,MED CTR,SCH MED,DEPT GENET,STANFORD,CA 94305
[4] BOSTON UNIV,SCH MED,DEPT NEUROL,BOSTON,MA 02118
[5] BOSTON UNIV,SCH PUBL HLTH,BOSTON,MA 02215
来源：
GENOMICS | 1990年 / 7卷 / 01期
关键词：
D O I：
10.1016/0888-7543(90)90525-Y
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Alpha satellite DNA is composed of variants of a short consensus sequence that are repeated in tandem arrays in the centromeric heterochromatin of each human chromosome. To define centromeric markers for linkage studies, we screened human genomic DNA for restriction fragment length polymorphisms using a probe detecting alphoid sequences on chromosomes 13 and 21. We describe one such DNA polymorphism. Analysis of linkage of this DNA marker to other polymorphic markers in the CEPH pedigrees demonstrates linkage to markers on the proximal long arm of chromosome 13 and defines the centromeric end of the linkage map of this chromosome. © 1990.
引用
收藏
页码：110 / 114
页数：5
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