ANGIOTENSIN-II STIMULATES ANGIOTENSINOGEN SYNTHESIS IN HEPATOCYTES BY A PERTUSSIS TOXIN-SENSITIVE MECHANISM

被引：16

作者：

KLETT, C ^{[1
]}

MULLER, F ^{[1
]}

GIERSCHIK, P ^{[1
]}

HACKENTHAL, E ^{[1
]}

机构：

[1] UNIV HEIDELBERG,DEPT PHARMACOL,NEUENHEIMER FELD 366,W-6900 HEIDELBERG,GERMANY

来源：

FEBS LETTERS | 1990年 / 259卷 / 02期

关键词：

(Rat hepatocyte); Adenosine monophosphate; 3'; 5'-cyclic; Angiotensin II; Angiotensinogen synthesis; Pertussis toxin;

D O I：

10.1016/0014-5793(90)80032-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The role of intracellular messengers in the stimulatory effect of angiotensin II on angiotensinogen synthesis and secretion in hepatocytes was examined. Angiotensinogen secretion was not influenced by modulators of intracellular calcium (calmidazolium, A 23187, Bay K 8644, methoxamine). In contrast, agents decreasing intracellular cAMP (angiotensin II, guanfacine) stimulated, and those increasing cAMP (isoproterenol, glucagon, forskolin) depressed angiotensinogen secretion. An inverse relationship was also observed between cAMP and angiotensinogen mRNA. Pretreatment of hepatocytes with pertussis toxin abolished the stimulation by angiotensin II. It is concluded that angiotensin II-induced stimulation of angiotensinogen synthesis is initiated by inhibition of adenylate cyclase. © 1990.

引用

页码：301 / 304

页数：4

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