IMPROVING TOXICOLOGY TESTING PROTOCOLS USING COMPUTER-SIMULATIONS

被引：9
作者：
CLEWELL, HJ [1 ]
ANDERSEN, ME [1 ]
机构：
[1] HARRY G ARMSTRONG AEROSP MED RES LAB,DIV TOX HAZARDS,WRIGHT PATTERSON AFB,OH 45433
来源：
TOXICOLOGY LETTERS | 1989年 / 49卷 / 2-3期
关键词：
D O I：
10.1016/0378-4274(89)90029-5
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
引用
收藏
页码：139 / 158
页数：20
相关论文
共 48 条
[1]   PHYSIOLOGICALLY BASED PHARMACOKINETICS AND THE RISK ASSESSMENT PROCESS FOR METHYLENE-CHLORIDE [J].
ANDERSEN, ME ;
CLEWELL, HJ ;
GARGAS, ML ;
SMITH, FA ;
REITZ, RH .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1987, 87 (02) :185-205
[2]   INHALATION PHARMACOKINETICS - EVALUATING SYSTEMIC EXTRACTION, TOTAL INVIVO METABOLISM, AND THE TIME COURSE OF ENZYME-INDUCTION FOR INHALED STYRENE IN RATS BASED ON ARTERIAL BLOOD - INHALED AIR CONCENTRATION RATIOS [J].
ANDERSEN, ME ;
GARGAS, ML ;
RAMSEY, JC .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1984, 73 (01) :176-187
[3]  
ANDERSEN ME, 1987, DRINKING WATER HLTH, V8, P8
[4]  
ANDERSEN ME, 1986, TOXICOLOGIST, V6, P148
[5]  
Bischoff K. B., 1966, CHEM ENG PROG S, V62, P33
[6]   RECEPTOR-MEDIATED PHARMACODYNAMICS OF PREDNISOLONE IN THE RAT [J].
BOUDINOT, FD ;
DAMBROSIO, R ;
JUSKO, WJ .
JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1986, 14 (05) :469-493
[7]   COMPARATIVE TOXICITY AND CARCINOGENICITY OF 2 CHLORINATED PARAFFINS IN F344/N RATS AND B6C3F1 MICE [J].
BUCHER, JR ;
ALISON, RH ;
MONTGOMERY, CA ;
HUFF, J ;
HASEMAN, JK ;
FARNELL, D ;
THOMPSON, R ;
PREJEAN, JD .
FUNDAMENTAL AND APPLIED TOXICOLOGY, 1987, 9 (03) :454-468
[8]  
Clewell H J 3rd, 1985, Toxicol Ind Health, V1, P111
[9]  
CLEWELL HJ, 1987, DRINKING WATER HLTH, V8, P159
[10]  
CLEWELL HJ, 1988, AVIAT SPACE ENV ME S, V59, pA1
12345