On a Class of Optimal Type Covariate Adjusted Response Adaptive Allocations for Normal Treatment Responses

被引：1

作者：

Bandyopadhyay, Uttam ^{[1
]}

Bhattacharya, Rahul ^{[1
]}

机构：

[1] Calcutta Univ, Dept Stat, 35 Ballygunge Circular Rd, Kolkata 700019, India

来源：

AUSTRIAN JOURNAL OF STATISTICS | 2015年 / 44卷 / 04期

关键词：

response adaptive design; covariate adjusted allocation; optimality;

D O I：

10.17713/ajs.v44i4.69

中图分类号：

O21 [概率论与数理统计]; C8 [统计学];

学科分类号：

020208 ; 070103 ; 0714 ;

摘要：

In the context of clinical trials for comparing two treatments, a new class of covariate adjusted response adaptive procedures is developed to achieve a balance between clinical optimality and inferential precision. Assuming normally distributed responses, several exact and asymptotic properties are studied and compared with a reasonable alternative under the presence of treatment covariate interaction.

引用

页码：53 / 65

页数：13

共 15 条

[1] OPTIMUM BIASED COIN DESIGNS FOR SEQUENTIAL CLINICAL-TRIALS WITH PROGNOSTIC FACTORS
ATKINSON, AC
[J]. BIOMETRIKA, 1982, 69 (01) : 61 - 67
[2] Optimal allocation to maximize the power of two-sample tests for binary response
Azriel, D.
Mandel, M.
Rinott, Y.
[J]. BIOMETRIKA, 2012, 99 (01) : 101 - 113
[3] Adaptive designs for normal responses with prognostic factors
Bandyopadhyay, U
Biswas, A
[J]. BIOMETRIKA, 2001, 88 (02) : 409 - 419
[4] TREATMENT ALLOCATION PROCEDURE FOR SEQUENTIAL CLINICAL-TRIALS
BEGG, CB
IGLEWICZ, B
[J]. BIOMETRICS, 1980, 36 (01) : 81 - 90
[5] Covariate-adjusted adaptive designs for continuous responses in a phase III clinical trial: Recommendation for practice
Biswas, A
Huang, HH
Huang, WT
[J]. JOURNAL OF BIOPHARMACEUTICAL STATISTICS, 2006, 16 (02) : 227 - 239
[6] Biswas A, 2004, CONTRIB STAT, P51
[7] Friedmen LM, 2010, FUNDAMENTALS OF CLINICAL TRIALS, FOURTH EDITION, P1
[8] Garret H.E., 1979, STAT PSYCHOL ED
[9] Hu F., 2006, THEORY RESPONSE ADAP
[10] Jennison C, 2000, GROUP SEQUENTIAL MET

← 1 2 →