AUGMENTATION OF MURINE HEMATOPOIESIS BY INTERLEUKIN 2-ACTIVATED IRRADIATED T-CELLS

被引：2

作者：

CHARAK, BS ^{[1
]}

BROWN, EG ^{[1
]}

MAZUMDER, A ^{[1
]}

机构：

[1] GEORGETOWN UNIV,MED CTR,BONE MARROW TRANSPLANTAT PROGRAM,WASHINGTON,DC 20007

来源：

TRANSPLANTATION | 1995年 / 60卷 / 06期

关键词：

D O I：

10.1097/00007890-199509270-00012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have examined the role of T cells activated with interleukin-2 (IL-2) in vitro and subsequently irradiated (2500 rads), in stimulating murine hematopoiesis in a syngeneic system. Our data suggest that activated, irradiated T (AIT) cells significantly increased the progenitor cell activity of T cell-depleted bone marrow (BM) both in vitro and in vivo as compared with controls (P<0.001). The efficacy of AIT cells was comparable to that of activated, nonirradiated T (AT) cells (P>0.05). Optimal stimulation of BM progenitor cell activity was seen when T cells were activated for 4 days and used in a BM to T cell ratio of 1:2 or 1:5. The effect of these activated cells was related to the release of factors with ability to enhance hematopoiesis. These observations may have implications in enhancing the engraftment of T cell-depleted BM in allogeneic transplantation.

引用

页码：589 / 594

页数：6