THE PRODUCTION OF GRANULOCYTE-COLONY-STIMULATING FACTOR AND INTERLEUKIN-6 BY HUMAN BONE-MARROW STROMAL CELLS IN APLASTIC-ANEMIA

被引：3

作者：

TANI, K ^{[1
]}

OZAWA, K ^{[1
]}

OGURA, H ^{[1
]}

TAKAHASHI, S ^{[1
]}

TAKAHASHI, K ^{[1
]}

TSURUTA, T ^{[1
]}

OKANO, A ^{[1
]}

AKIYAMA, Y ^{[1
]}

YOSHIKUBO, T ^{[1
]}

SHIMANE, M ^{[1
]}

ASANO, S ^{[1
]}

机构：

[1] AJINOMOTO CO INC, CENT RES LABS, KAWASAKI, KANAGAWA 210, JAPAN

来源：

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE | 1993年 / 169卷 / 04期

关键词：

BONE MARROW STROMAL CELLS; GRANULOCYTE COLONY-STIMULATING FACTOR; INTERLEUKIN-6; APLASTIC ANEMIA;

D O I：

10.1620/tjem.169.325

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Stromal cells are known to produce granulocyte colony-stimulating factor (G-CSF) and interleukin 6 (IL-6). To assess the function of bone marrow stromal cells in the pathological state, we studied their in vitro ability to produce G-CSF and IL-6 in 9 patients with aplastic anemia and 5 normal volunteers, using an enzyme immunoassay method. Constitutive production of IL-6, but not G-CSF, was detected in almost all cases. Interestingly, the inducible production of G-CSF and IL-6 by stromal cells after stimulation with interleukin-1 and/or lipopolysaccharides was severely depressed in 3 patients with aplastic anemia. Our results may reflect poor hematopoietic activity in the bone marrow in some cases of aplastic anemia.

引用

页码：325 / 334

页数：10

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