TELOMERE DIRECTED FRAGMENTATION OF MAMMALIAN CHROMOSOMES

被引：132

作者：

BARNETT, MA

BUCKLE, VJ

EVANS, EP

PORTER, ACG

ROUT, D

SMITH, AG

BROWN, WRA

机构：

[1] UNIV OXFORD,DEPT BIOCHEM,S PARKS RD,OXFORD OX1 3QU,ENGLAND

[2] JOHN RADCLIFFE HOSP,INST MOLEC MED,OXFORD OX3 9DU,ENGLAND

[3] MRC,RADIOBIOL UNIT,DIDCOT OX11 0RD,OXON,ENGLAND

[4] UNIV EDINBURGH,AFRC,CTR GENOME RES,EDINBURGH EH9 3JQ,SCOTLAND

来源：

NUCLEIC ACIDS RESEARCH | 1993年 / 21卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1093/nar/21.1.27

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cloned human telomeric DNA can integrate into mammalian chromosomes and seed the formation of new telomeres. This process occurs efficiently in three established human cell lines and in a mouse embryonic stem cell line. The newly seeded telomeres appear to be healed by telomerase. The seeding of new telomeres by cloned telomeric DNA is either undetectable or very inefficient in non-tumourigenic mouse or human somatic cell lines. The cytogenetic consequences of the seeding of new telomeres include large chromosome truncations but most of the telomere seeding events occur close to the pre-existing ends of natural chromosomes.

引用

页码：27 / 36

页数：10

共 22 条

[1] MAPPING OF THE ONCOGENES MYC, SIS, AND INT-1 TO THE DISTAL PART OF MOUSE CHROMOSOME-15 [J].