SYNTHESIS, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY OF METAL (II) COMPLEXES OF 2-ACETYLPYRIDINE THIOSEMICARBAZONES

被引：0
|
作者：
OFFIONG, OE
MARTELLI, S
机构：
[1] UNIV CAMERINO,DIPARTIMENTO SCI CHIM,I-62032 CAMERINO,ITALY
[2] UNIV CALABAR,DEPT CHEM,CALABAR,NIGERIA
来源：
FARMACO | 1993年 / 48卷 / 06期
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
2-Acetylpyridine-(4-methylthiosemicarbazone), 2-acetylpyridine-(2-methylthiosemicarbazone) and their metal (II) complexes have been synthesized and characterized by chemical and spectral methods. They were studied for their antibacterial, antifungal and amoebicidal activity in vitro and for their toxicity in vivo. The ligands and their metal (II) complexes exibited significant activity against a wide spectrum of microorganisms. The metal (II) complexes derived from 2-acetylpyridine-(4-methylthiosemicarbazone) seem to be the most active compounds.
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页码：777 / 793
页数：17
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