The Rho/Rho-kinase Systems Are Involved in Rapid Pacing-induced Changes of Atrial Refractory Period in a Canine Model

被引：0

作者：

Furusho, Hiroshi ^{[1
]}

Sakagami, Satoru ^{[3
]}

Takamura, Masayuki ^{[1
]}

Kitano, Katsunori ^{[1
]}

Abe, Tsuyoshi ^{[1
]}

Hirazawa, Motoaki ^{[1
]}

Usui, Soichiro ^{[1
]}

Okajima, Masaki ^{[1
]}

Saeki, Takahiro ^{[1
]}

Maruyama, Michiro ^{[1
]}

Kaneko, Shuichi ^{[1
]}

Takata, Sigeo ^{[2
]}

机构：

[1] Kanazawa Univ, Grad Sch Med Sci, Dept Cardiol, 13-1 Takara Machi, Kanazawa, Ishikawa 9208641, Japan

[2] Kanazawa Univ, Fac Med, Dept Hlth Sci, Kanazawa, Ishikawa, Japan

[3] Kanazawa Med Ctr, Dept Cardiol, Kanazawa, Ishikawa, Japan

来源：

JOURNAL OF ARRHYTHMIA | 2006年 / 22卷 / 03期

关键词：

Fasudil; Electrophysiology; Effective refractory period; Rho-kinase inhibitor;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: The Rho/Rho-kinase pathway has been related to various physiological responses of the cardiovascular system. Previous reports have suggested a significant effect of Rho signals on the electrophysiological characteristics of the heart. We hypothesized that the Rho/Rho-kinase system would contribute to the rapid pacing-related change of atrial effective refractory period (AERP). Methods and Results: In 17 dogs, AERP was measured at the right atrial appendage (RAA) and posterior left atrium ( LA) before, during, and after 6-hours rapid atrial pacing at 500 bpm. Saline control (n = 5), verapamil (n = 5), or fasudil (n = 7) were infused throughout the protocol. The shortening of AERP after rapid pacing was abrogated by the administration of verapamil, as reported in previous studies. Furthermore, fasudil (Rho/Rho-kinase inhibitor) influenced the change of AERP in a manner similar to the infusion of verapamil throughout the experiments. Conclusions: Since the AERP was attenuated by fasudil, rapid pacing-related atrial electrophysiological changes might involve the Rho/Rho-kinase pathway.

引用

页码：167 / 173

页数：7