PORCINE PANCREAS EXTRACT DECREASES BLOOD-IONIZED CALCIUM IN MICE AND INHIBITS OSTEOCLAST FORMATION AND BONE-RESORPTION IN CULTURE

被引：9

作者：

YONEDA, T

TAKAOKA, Y

ALSINA, MM

GARCIA, J

MUNDY, GR

机构：

[1] Division of Endocrinology and Metabolism, Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio

来源：

FEBS LETTERS | 1991年 / 278卷 / 02期

关键词：

ACUTE PANCREATITIS; HYPOCALCEMIA; BONE RESORPTION; OSTEOCLAST; PORCINE PANCREAS;

D O I：

10.1016/0014-5793(91)80109-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Patients with acute pancreatitis commonly manifest hypocalcemia for reasons which are unknown. We found that porcine pancreas extracts (PX) significantly decreased blood-ionized calcium in Balb/c mice. Partially-purified PX with a molecular mass of approximately 27 kDa decreased blood-ionized calcium in the mice. Partially-purified PX suppressed not only Ca-45 release from fetal rat long bones which had been stimulated by parathyroid hormone, interleukin-1-alpha, tumor necrosis factor, transforming growth factor-alpha, 1,25-dihydroxyvitamin D3 and prostaglandin E2, but tartrate-resistant acid phosphatase-positive multinucleated cell formation in the presence of 1,25-dihydroxyvitamin D3 in mouse marrow cultures. The results suggest that there is an as yet-unidentified bone metabolism-regulating substance in porcine pancreas which might be responsible for the hypocalcemia associated with acute pancreatitis.

引用

页码：171 / 174

页数：4

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