TOBACCO-SMOKE SUPPRESSES T-CELLS BUT NOT ANTIGEN-PRESENTING CELLS IN THE LUNG-ASSOCIATED LYMPH-NODES

被引:22
作者
CHANG, JCC
DISTLER, SG
KAPLAN, AM
机构
[1] Department of Microbiology and Immunology, University of Kentucky Medical Center, Lexington
关键词
D O I
10.1016/0041-008X(90)90046-W
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Chronic inhalation of cigarette smoke in mice preferentially inhibited the antigen-specific T-cell proliferative response of lung-associated lymph nodes compared to anatomically distant lymph nodes. Cell mixing experiments demonstrated that the defect in smoked mice resulted from an abnormality in T-lymphocyte function. In contrast, the activity of antigen-presenting cells was similar in smoked and sham-smoked control animals. These results suggest that T-cell function in lung-associated lymphoid tissue may be inhibited in smokers, leading to a localized predisposition to respiratory tract infections. © 1990.
引用
收藏
页码:514 / 523
页数:10
相关论文
共 37 条
[1]  
ANDERSEN P, 1982, CLIN EXP IMMUNOL, V47, P467
[2]  
ASHWELL JD, 1985, FED PROC, V44, P2475
[3]   LUNG RESPONSE TO ANTIGEN [J].
BICE, DE ;
MUGGENBURG, BA .
SEMINARS IN RESPIRATORY MEDICINE, 1984, 5 (03) :217-228
[4]   INHALATION TOXICITY STUDIES ON CIGARETTE-SMOKE .4. EXPRESSION OF DOSE OF SMOKE PARTICULATE MATERIAL APPLIED TO LUNGS OF EXPERIMENTAL-ANIMALS [J].
BINNS, R .
TOXICOLOGY, 1977, 7 (02) :189-195
[5]   ALVEOLAR MACROPHAGE REPLICATION - ONE MECHANISM FOR THE EXPANSION OF THE MONONUCLEAR PHAGOCYTE POPULATION IN THE CHRONICALLY INFLAMED LUNG [J].
BITTERMAN, PB ;
SALTZMAN, LE ;
ADELBERG, S ;
FERRANS, VJ ;
CRYSTAL, RG .
JOURNAL OF CLINICAL INVESTIGATION, 1984, 74 (02) :460-469
[6]   Kinetic Differences in Unresponsiveness of Thymus and Bone Marrow Cells [J].
Chiller, Jacques M. ;
Habicht, Gail S. ;
Weigle, William O. .
JOURNAL OF IMMUNOLOGY, 2013, 191 (03) :989-991
[7]   ALTERATIONS IN IMMUNOREGULATORY T-CELL SUBSETS IN CIGARETTE SMOKERS - A PHENOTYPIC ANALYSIS OF BRONCHOALVEOLAR AND BLOOD-LYMPHOCYTES [J].
COSTABEL, U ;
BROSS, KJ ;
REUTER, C ;
RUHLE, KH ;
MATTHYS, H .
CHEST, 1986, 90 (01) :39-44
[8]  
DANIELE RP, 1977, AM REV RESPIR DIS, V116, P997
[9]  
DANIELE RP, 1979, B EUR PHYSIOPATHOL R, V15, P26
[10]  
ELLIOTT LH, 1984, J IMMUNOL, V132, P1208