NORMAL LYMPHOCYTE INTERFERON-PRODUCTION IN ADULT HBSAG-POSITIVE CHRONIC ACTIVE LIVER-DISEASE

被引：5

作者：

PONZETTO, A ^{[1
]}

ZUCCA, M ^{[1
]}

MARCUCCI, F ^{[1
]}

RIZZETTO, M ^{[1
]}

ACTIS, GC ^{[1
]}

BONINO, F ^{[1
]}

GIOANNINI, P ^{[1
]}

机构：

[1] UNIV TURIN,SCH INFECT DIS,I-10126 TURIN,ITALY

来源：

JOURNAL OF MEDICAL VIROLOGY | 1979年 / 4卷 / 01期

关键词：

chronic active liver disease; hepatitis‐B surface antigen; interferon;

D O I：

10.1002/jmv.1890040106

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

To challenge the hypothesis that interferon (IF) production in chronic hepatitis‐B virus liver disease is defective, lymphocytes from 14 patients with chronic active liver disease (CALD); from nine patients with chronic inactive liver disease (CILD), and from six healthy chronic carriers (HCC) were stimulated by Newcastle Disease virus. The patients with CILD showed a weak IF response by comparison with the controls (P < 0.0005), whereas IF production by CALD patients and the HCC did not statistically differ from IF production in the healthy hepatitis‐B surface antigen negative subjects who served as controls. These results indicate that IF treatment of CALD does not rely on a completely proved background. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：43 / 50

页数：8

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