CLASS-II MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) GENE-EXPRESSION IN THE MOUSE-BRAIN IS ELEVATED IN THE AUTOIMMUNE MRL/MP-LPR/LPR STRAIN

被引：9

作者：

MCINTYRE, KR ^{[1
]}

AYERLELIEVRE, C ^{[1
]}

PERSSON, H ^{[1
]}

机构：

[1] KAROLINSKA INST,DEPT HISTOL & NEUROBIOL,S-10401 STOCKHOLM 60,SWEDEN

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1990年 / 28卷 / 01期

关键词：

Autoimmunity; Brain; Central nervous system; Ia; mRNA; Systemic lupus erythematosus;

D O I：

10.1016/0165-5728(90)90039-P

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Brain levels of Ia mRNA, quantified by RNA blot analysis, were found to be 30-50-fold lower than splenic levels in all autoimmune and normal mouse strains examined except MRL/1, whose brain content of Ia mRNA was comparable to normal splenic levels. Prior perfusion to remove blood cells did not alter the amount of Ia mRNA obtainable from MRL/1 brain. Elevation of Ia mRNA in MRL/1 as compared to control C3H mice was also found in kidney, liver, spleen, though not in thymus or lung. Results are discussed in relation to an animal model for central nervous system involvement in systemic lupus erythematosus. © 1990.

引用

页码：39 / 52

页数：14

共 50 条

[31] EXPRESSION OF CLASS-II MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGENS ON PANCREATIC B-CELLS IN THE NOD MOUSE
HANAFUSA, T
FUJINOKURIHARA, H
MIYAZAKI, A
YAMADA, K
NAKAJIMA, H
MIYAGAWA, J
KONO, N
TARUI, S
DIABETOLOGIA, 1987, 30 (02) : 104 - 108
[32] CHROMATIN STRUCTURE OF THE HLA-DR-ALPHA GENE IN DIFFERENT FUNCTIONAL-STATES OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II GENE-EXPRESSION
PETERLIN, BM
HARDY, KJ
LARSEN, AS
MOLECULAR AND CELLULAR BIOLOGY, 1987, 7 (05) : 1967 - 1972
[33] CLASS-II MAJOR HISTOCOMPATIBILITY COMPLEX (MHC-II) MOLECULE EXPRESSION BY ASTROCYTES IN CHRONICALLY DEMYELINATED CNS TISSUE INVITRO
CANNELLA, B
BORNSTEIN, MB
RAINE, CS
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1991, 50 (03): : 297 - 297
[34] ULTRASTRUCTURAL LOCATION OF MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) CLASS-II POSITIVE PERIVASCULAR CELLS IN HISTOLOGICALLY NORMAL HUMAN BRAIN
GRAEBER, MB
STREIT, WJ
BURINGER, D
SPARKS, DL
KREUTZBERG, GW
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1992, 51 (03): : 303 - 311
[35] Major histocompatibility complex class II (MHC II) expression during development of human fetal brain and haemopoietic organs
Wierzba-Bobrowicz, T
Kosno-Kruszewska, E
Lewandowska, E
Lechowicz, W
Schmidt-Sidor, B
PROGRESS IN BASIC AND CLINICAL IMMUNOLOGY, 2001, 495 : 93 - 101
[36] A HIGHLY POLYMORPHIC MICROSATELLITE IN THE CLASS-II EB GENE ALLOWS TRACING OF MAJOR HISTOCOMPATIBILITY COMPLEX EVOLUTION IN MOUSE
SAHA, BK
SHIELDS, JJ
MILLER, RD
HANSEN, TH
SHREFFLER, DC
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (11) : 5312 - 5316
[37] DIFFERENTIAL EXPRESSION OF CLASS-II MAJOR HISTOCOMPATIBILITY COMPLEX AND THY-I.2 ANTIGENS ON MOUSE DECIDUA
SEARLE, RF
MATTHEWS, CJ
PLACENTA, 1988, 9 (01) : 57 - 64
[38] THERAPY OF AUTOIMMUNE-DISEASE WITH MONOCLONAL-ANTIBODIES TO CLASS-II GENE-PRODUCTS OF THE MAJOR HISTOCOMPATIBILITY COMPLEX
STEINMAN, L
PROGRESS IN ALLERGY, 1988, 45 : 161 - 167
[39] Major histocompatibility complex (Mhc) class Ib gene duplications, organization and expression patterns in mouse strain C57BL/6
Masato Ohtsuka
Hidetoshi Inoko
Jerzy K Kulski
Shinichi Yoshimura
BMC Genomics, 9
[40] Major histocompatibility complex (Mhc) class Ib gene duplications, organization and expression patterns in mouse strain C57BL/6
Ohtsuka, Masato
Inoko, Hidetoshi
Kulski, Jerzy K.
Yoshimura, Shinichi
BMC GENOMICS, 2008, 9 (1)

← 1 2 3 4 5 →