SHORT-TERM TOXICITY OF BLACK-PN IN PIGS

Black PN was fed to pigs at levels of 0 (control), 100, 300 or 900 mg/kg/day. There were no adverse effects on growth, haematology, urine analyses, serum transaminase activities or organ weights. Cysts containing mucus and fibrin were found in the mucosa of the ileum of four of the six pigs given the highest level of treatment and one of six given 300 mg/kg/day. It is suggested that this may have been due to an irritant effect of local high concentrations of the colouring. The no-effect level of 100 mg/kg/day is 600-800 times the likely maximum intake by man. © 1969 Pergamon Press Limited.