STRIATAL DOPAMINE-MEDIATED MOTOR BEHAVIOR IS ALTERED FOLLOWING OCCLUSION OF THE MIDDLE CEREBRAL-ARTERY

被引：38
作者：
BORLONGAN, CV
MARTINEZ, R
SHYTLE, RD
FREEMAN, TB
CAHILL, DW
SANBERG, PR
机构：
[1] UNIV S FLORIDA,COLL MED,DEPT SURG,DIV NEUROL SURG,TAMPA,FL 33612
[2] UNIV S FLORIDA,COLL MED,DEPT NEUROL,TAMPA,FL
[3] UNIV S FLORIDA,COLL MED,DEPT PSYCHIAT,TAMPA,FL
[4] UNIV S FLORIDA,COLL MED,DEPT PHARMACOL,TAMPA,FL
来源：
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1995年 / 52卷 / 01期
关键词：
STROKE; MIDDLE CEREBRAL ARTERY; STRIATUM; DOPAMINE; HALOPERIDOL; AMPHETAMINE; CATALEPSY; LOCOMOTOR BEHAVIOR; AGING;
D O I：
10.1016/0091-3057(95)00108-9
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Cerebral infarct (stroke) causes striatal damage with subsequent deterioration of sensorimotor and cognitive functions that may be mediated by the dopamine receptor system. In the present study, transient, focal ischemia was induced in Sprague-Dawley rats by middle cerebral artery occlusion. Ischemic animals exhibited significantly less dopamine antagonist (haloperidol)-induced catalepsy and more dopamine agonist (amphetamine)-induced hyperactivity than sham-operated animals. Younger ischemic animals showed more profound behavioral alteration but also displayed greater recovery over time than older ischemic animals. Histologic data revealed a lateral striatal lesion in all ischemic animals. These results place the striatal dopaminergic system as a possible strategic venue for the treatment of cerebral ischemia. In addition, aging is found to be a risk factor for stroke as noted in humans.
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收藏
页码：225 / 229
页数：5
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