COGNITIVE IMPAIRMENTS INDUCED BY TRIAZOLAM IN HEALTHY-VOLUNTEERS - ANTAGONISM BY A PARTIAL INVERSE AGONIST OF BENZODIAZEPINE RECEPTOR

被引：0

作者：

WAROT, D ^{[1
]}

DANJOU, P ^{[1
]}

DOUILLET, P ^{[1
]}

KEANE, P ^{[1
]}

PUECH, AJ ^{[1
]}

机构：

[1] SANOFI RECH,F-34184 MONTPELLIER 04,FRANCE

来源：

THERAPIE | 1994年 / 49卷 / 01期

关键词：

COGNITIVE FUNCTIONS; HEALTHY VOLUNTEERS; TRIAZOLAM; BZ RECEPTOR PARTIAL INVERSE AGONIST;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Pharmacological studies revealed that SR 25776 possesses marked stimulant activity characteristic of a partial inverse agonist of benzodiazepine receptor The effects of SR 25776 500 mg alone and in combination with triazolam 0.25 mg on psychomotor performance and memory were assessed in 8 healthy consenting male volunteers in a double-blind placebo controlled trial. Treatment effects were monitored before and two and half hours following oral medication. The present study suggest that at the studied dose SR 25776 may incompletely antagonize the sedative and amnesic effects of a benzodiazepine agonist without producing marked effects of its own.

引用

页码：23 / 26

页数：4

共 21 条

[11]

EVES FF, PSYCHOPHARMACOLOGY, V95, P386

[12] INTRINSIC ACTIONS OF THE BENZODIAZEPINE RECEPTOR ANTAGONIST RO-15-1788 [J].