DETERMINATION OF SULTHIAME, TETRAHYDRO-2-PARA-SULPHAMOYL-PHENYL-2H-1,2-THIAZINE-1,1-DIOXIDE, IN PLASMA AT THERAPEUTIC CONCENTRATIONS, USING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：8

作者：

BERRY, DJ

CLARKE, LA

VALLINS, GE

机构：

[1] Poisons Unit, New Cross Hospital, London, SE14 5ER, Avonley Road

来源：

JOURNAL OF CHROMATOGRAPHY | 1979年 / 171卷 / APR期

关键词：

D O I：

10.1016/S0021-9673(01)95316-6

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A specific and sensitive liquid chromatographic method for the determination of sulthiame in small (0.5 ml) plasma samples is described. After adding an internal standard, a direct extract of the sample is examined by reversed-phase liquid chromatography with ultraviolet spectrophotometric detection. The method is rapid, simple and capable of determining plasma levels after therapeutic ingestio of sulthiame. © 1979.

引用

页码：363 / 370

页数：8

共 12 条

[1]

BERRY DJ, UNPUBLISHED

[2]

CALLAGHAN N, 1977, EPILEPSY, P119

[3]

FLACHS H, 1977, ANTIEPILEPTIC DRUG M, P165

[4] SIMULTANEOUS DETERMINATION OF SULTHIAME AND DIPHENYLHYDANTOIN SERUM LEVELS BY GAS-LIQUID CHROMATOGRAPHY [J].