PARALLEL GENOME ANALYSIS BY 2-DIMENSIONAL DNA TYPING

被引：23

作者：

MULLAART, E ^{[1
]}

DEVOS, GJ ^{[1
]}

MEERMAN, GJT ^{[1
]}

UITTERLINDEN, AG ^{[1
]}

VIJG, J ^{[1
]}

机构：

[1] UNIV GRONINGEN,DEPT MED GENET,9713 AW GRONINGEN,NETHERLANDS

来源：

NATURE | 1993年 / 365卷 / 6445期

关键词：

D O I：

10.1038/365469a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

By two-dimensional (2-D) DNA typing a restriction enzyme digest of genomic DNA can be resolved on the basis of both size and base-pair sequence and subsequently analysed by repeat probe hybridization to reveal sequence variants at multiple genomic sites in parallel. The system has been partly automated and allows for large-scale comparative analysis of complex genomes in a cost-effective manner.

引用

页码：469 / 471

页数：3

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