HIV-SPECIFIC CYTOTOXIC T-CELL ACTIVITY IN AN HIV-EXPOSED BUT UNINFECTED INFANT

被引：359
|
作者：
ROWLANDJONES, SL
NIXON, DF
ALDHOUS, MC
GOTCH, F
ARIYOSHI, K
HALLAM, N
KROLL, JS
FROEBEL, K
MCMICHAEL, A
机构：
[1] UNIV OXFORD,JOHN RADCLIFFE HOSP,DEPT PAEDIAT,OXFORD OX3 9DU,ENGLAND
[2] JOHN RADCLIFFE HOSP,PUBL HLTH LAB,DEPT VIROL,OXFORD OX3 9DU,ENGLAND
[3] UNIV EDINBURGH,ROYAL EDINBURGH INFIRM,DEPT MED,HIV IMMUNOL UNIT,EDINBURGH EH10 5HF,MIDLOTHIAN,SCOTLAND
[4] ST MARYS HOSP,SCH MED,DEPT GENITOURINARY MED,LONDON,ENGLAND
来源：
LANCET | 1993年 / 341卷 / 8849期
关键词：
D O I：
10.1016/0140-6736(93)93063-7
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The factors necessary for protective immunity against HIV-1 are unknown. Important information about these factors should come from study of people at high risk of HIV infection who have not apparently become infected. Among these are the estimated 60-85% of children who may be exposed in utero or perinatally to HIV-1 but do not become infected. We observed the transient appearance of HIV-specific cytotoxic T-lymphocyte (CTL) activity in a baby born to HIV-1-infected parents, in whom all standard markers of infection remained negative. These findings suggest that HIV-specific CTLs may be a marker for recently exposed, but uninfected, individuals.
引用
收藏
页码：860 / 861
页数：2
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