INTERACTION BETWEEN LYMPHOKINE ACTIVATED KILLER-CELLS GENERATED IN THE PRESENCE OF CISPLATIN FK-565 AND TUMOR-CELLS - TRANSMISSION ELECTRON-MICROSCOPY ANALYSIS

被引：1

作者：

BASU, S ^{[1
]}

SODHI, A ^{[1
]}

机构：

[1] BANARAS HINDU UNIV, SCH BIOTECHNOL, VARANASI 221005, UTTAR PRADESH, INDIA

来源：

ANTI-CANCER DRUGS | 1992年 / 3卷 / 02期

关键词：

LYMPHOKINE ACTIVATED KILLER CELLS; CISPLATIN; FK-565;

D O I：

10.1097/00001813-199204000-00014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lymphokine activated killer (LAK) cells generated in the presence of cisplatin/FK-565 along with interleukin-2 (IL-2) showed enhanced binding to tumor cells as compared with LAK cells generated in the presence of IL-2 alone. The LAK cells showed a reorientation of cellular organelles in the presence of tumor cells. LAK-tumor conjugate pairs showed vesicle-like structures in the extracellular pockets. The number of vesicles in the extracellular pockets was found to be increased in the case of LAK cells generated in the presence of cisplatin/FK-565 along with IL-2. The closer interaction between the LAK cell-target cell and the large number of vesicles in the extracellular space of conjugate pairs may explain the increased lysis of target cells by LAK cells generated in the presence of cisplatin/FK-565 along with IL-2 as compared with IL-2 alone.

引用

页码：155 / 162

页数：8

共 37 条

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