PHARMACOLOGICAL ACTIVITY OF THE CANNABINOID RECEPTOR AGONIST, ANANDAMIDE, A BRAIN CONSTITUENT

被引：392

作者：

FRIDE, E ^{[1
]}

MECHOULAM, R ^{[1
]}

机构：

[1] HEBREW UNIV JERUSALEM,SCH PHARM,DEPT NAT PROD,IL-91120 JERUSALEM,ISRAEL

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 231卷 / 02期

关键词：

CANNABINOIDS; TETRAHYDROCANNABINOL; MARIJUANA;

D O I：

10.1016/0014-2999(93)90468-W

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Anandamide (arachidonylethanolamide) is a brain constituent which binds to the cannabinoid receptor. We now report the first in vivo examination of this ligand. Anandamide administered i.p. in mice, caused lowering of activity in an immobility and in an open field test, and produced hypothermia and analgesia. These effects parallel those caused by psychotropic cannabinoids.

引用

页码：313 / 314

页数：2

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