THE SYNTHESIS AND INVITRO ACETYLCHOLINESTERASE AND BUTYRYLCHOLINESTERASE INHIBITORY ACTIVITY OF TACRINE (COGNEX(R)) DERIVATIVES

被引：68
|
作者：
GREGOR, VE
EMMERLING, MR
LEE, C
MOORE, CJ
机构：
[1] Parke-Davis Pharmaceutical Research, Warner-Lambert Co., Ann Arbor
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 08期
关键词：
D O I：
10.1016/S0960-894X(00)80545-4
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Chlorosubstituted derivatives of tacrine (1), 1,4-methylenetacrine (2), and their in vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities are described. The most potent analogues are 6-chlorotacrine (1b) in AChE and 7-chlorotacrine (1c) in BChE inhibition.
引用
收藏
页码：861 / 864
页数：4
相关论文
共 50 条
  • [1] Synthesis and acetylcholinesterase/butyrylcholinesterase inhibition activity of new tacrine-like analogues
    Marco, JL
    de los Ríos, C
    Carreiras, MC
    Baños, JE
    Badía, A
    Vivas, NM
    BIOORGANIC & MEDICINAL CHEMISTRY, 2001, 9 (03) : 727 - 732
  • [2] The oxidation products of melatonin derivatives exhibit acetylcholinesterase and butyrylcholinesterase inhibitory activity
    Siwicka, Aleksandra
    Moleda, Zuzanna
    Wojtasiewicz, Krystyna
    Zawadzka, Anna
    Maurin, Jan K.
    Panasiewicz, Miroslawa
    Pacuszka, Tadeusz
    Czarnocki, Zbigniew
    JOURNAL OF PINEAL RESEARCH, 2008, 45 (01) : 40 - 49
  • [3] Synthesis of Imidazole-Thiazole Derivatives as Acetylcholinesterase and Butyrylcholinesterase Inhibitory Activities
    Abdüllatif Karakaya
    Ulviye Acar Çevik
    Tuğba Erçetin
    Yusuf Özkay
    Zafer Asım Kaplancıklı
    Pharmaceutical Chemistry Journal, 2023, 57 : 1439 - 1443
  • [4] Kinetic analysis of the toxicological effect of tacrine (Cognex®) on human retinal acetylcholinesterase activity
    Alhomida, AS
    Al-Rajhi, AA
    Kamal, MA
    Al-Jafari, AA
    TOXICOLOGY, 2000, 147 (01) : 33 - 39
  • [5] Synthesis of Imidazole-Thiazole Derivatives as Acetylcholinesterase and Butyrylcholinesterase Inhibitory Activities
    Karakaya, Abduellatif
    Cevik, Ulviye Acar
    Ercetin, Tugba
    Ozkay, Yusuf
    Kaplancikli, Zafer Asim
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2023, 57 (09) : 1439 - 1443
  • [6] THE EFFECT OF TACRINE AND SELECTED METABOLITES ON RAT ACETYLCHOLINESTERASE AND BUTYRYLCHOLINESTERASE ACTIVITY
    SCHWARZ, RD
    CHANG, T
    DAVIS, RE
    MOOS, WH
    PAVIA, M
    SPENCER, CJ
    THOMAS, AJ
    NEUROBIOLOGY OF AGING, 1990, 11 (03) : 349 - 349
  • [7] Synthesis and biological evaluation of phloroglucinol derivatives possessing -glycosidase, acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase inhibitory activity
    Burmaoglu, Serdar
    Yilmaz, Ali O.
    Taslimi, Parham
    Algul, Oztekin
    Kilic, Deryanur
    Gulcin, Ilhami
    ARCHIV DER PHARMAZIE, 2018, 351 (02)
  • [8] Synthesis and molecular modelling of thiadizole based hydrazone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitory activities
    Isik, A.
    Cevik, U. Acar
    Karayel, A.
    Celik, I
    Ercetin, T.
    Kocak, A.
    Ozkay, Y.
    Kaplancikli, Z. A.
    SAR AND QSAR IN ENVIRONMENTAL RESEARCH, 2022, 33 (03) : 193 - 214
  • [9] Synthesis and acetylcholinesterase inhibitory activity of polymethoxyflavone Mannich base derivatives
    Ling Shi
    Yanhua Zhang
    Caifang Wang
    Haoran Liu
    Qiuan Wang
    Chemical Research in Chinese Universities, 2017, 33 : 594 - 597
  • [10] Synthesis and Acetylcholinesterase Inhibitory Activity of Polymethoxyflavone Mannich Base Derivatives
    Shi Ling
    Zhang Yanhua
    Wang Caifang
    Liu Haoran
    Wang Qiuan
    CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2017, 33 (04) : 594 - 597
12345