ALLELES OF THE RAT T-CELL RECEPTOR BETA-CHAIN GENE-COMPLEX

被引：0

作者：

BLANKENHORN, EP ^{[1
]}

SMITH, PD ^{[1
]}

WILLIAMS, CB ^{[1
]}

GUTMAN, GA ^{[1
]}

机构：

[1] UNIV CALIF IRVINE,CALIF COLL MED,DEPT MICROBIOL & MOLEC GENET,IRVINE,CA 92717

来源：

IMMUNOGENETICS | 1992年 / 35卷 / 05期

关键词：

D O I：

暂无

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Inbred rat strains provide a rich source of genetic diversity in immunologically relevant genes. We have characterized the alleles of one of these genes, encoding the rat T-cell receptor C-beta-1 chain, by Southern blots and nucleic acid sequencing. The Cb1 gene segments from DA and LEW rats display complex allotypic variation: both coding and noncoding regions contain multiple nucleotide substitutions. In addition, there is a polymorphic insertion of a rat repetitive LINE element 3' to the coding region. The Cb1 alleles are one part of larger Tcrb haplotypes, containing V-beta, D-beta, and J-beta elements; complete Cb1 genomic nucleotide sequences, and a partial list of the strain distribution of the two alleles, are described in this report.

引用

页码：324 / 331

页数：8

共 23 条

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