Hodgkin lymphoma, hypereosinophilic syndrome and renal failure: A case presentation

Hodgkin lymphoma (Hl) accounts for 9% of malignancies in pediatric patients. it is more frequent in males and its clinical presentation has 2 peaks. The first one is between the second and third decade, and the second peak is around 60 years old. Most of the neoplastic mass is constituted by an iniltrate of inlammatory cells and ibrosis, while malignant cells represent only 0.1% to 10% of the cell population. The Reed Sternberg cell is a classic inding in Hl. We report a case of a female teenager who develops an obstructive acute renal failure due to a retroperitoneal nodal conglomerate which was identiied as mixed cellularity subtype of HL (MCHL). In this patient the association with hypereosinophilic syndrome (HES) was also found. A third of patients with HL initially presents as an abdominal primary tumor. Hypereosinophylic syndrome as a paraneoplastic disorder is found in 15% of all cases. in order to make this diagnosis, leukemia, allergic diseases and parasitic infections must be excluded. In our patient the management with steroids and HL speciic chemotherapy resulted in a sat isfactory response observed in the reduction of the eosinophil count and size of linfadenopathies. The acute renal failure was resolved with peritoneal dialysis without tissue injury of the kidney so, it was no t affected by the hypereosinophylic syndrome. Renal tissue involvement is not described as a typical inding in HES. 1665-9201 (C) 2014 Gaceta Mexicana de Oncologia. Publicado por Masson Doyma Mexico S.A. Todos los derechos reservados.