LONG-TERM, HIGH-DOSE DISULFIRAM IN THE TREATMENT OF ALCOHOL-ABUSE

被引：16

作者：

BREWER, C

机构：

[1] The Stapleford Centre, London SW1W 9NP

来源：

BRITISH JOURNAL OF PSYCHIATRY | 1993年 / 163卷

关键词：

D O I：

10.1192/bjp.163.5.687

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

A patient who had experienced most of the standard methods of managing alcohol abuse found that during 11 years of treatment, the most consistently effective intervention has been the taking of disulfiram under family supervision. He has received 600 mg daily almost continuously for over six years without side-effects. Smaller doses do not have an adequate deterrent effect.

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页码：687 / 689

页数：3

相关论文

共 11 条

[1]

*ALC AN, 1975, LIV SOB

[2] LACK OF BIOEQUIVALENCE BETWEEN DISULFIRAM FORMULATIONS - EXEMPLIFIED BY A TABLET EFFERVESCENT TABLET STUDY [J].

ANDERSEN, MP .

ACTA PSYCHIATRICA SCANDINAVICA, 1992, 86 :31-35

[3] ALCOHOLISM-TREATMENT BY DISULFIRAM AND COMMUNITY REINFORCEMENT THERAPY [J].

AZRIN, NH ;

SISSON, RW ;

MEYERS, R ;

GODLEY, M .

JOURNAL OF BEHAVIOR THERAPY AND EXPERIMENTAL PSYCHIATRY, 1982, 13 (02) :105-112

[4] HOW EFFECTIVE IS THE STANDARD DOSE OF DISULFIRAM - A REVIEW OF THE ALCOHOL-DISULFIRAM REACTION IN PRACTICE [J].

BREWER, C .

BRITISH JOURNAL OF PSYCHIATRY, 1984, 144 (FEB) :200-202

[5] COMBINING PHARMACOLOGICAL ANTAGONISTS AND BEHAVIORAL PSYCHOTHERAPY IN TREATING ADDICTIONS - WHY IT IS EFFECTIVE BUT UNPOPULAR [J].

BREWER, C .

BRITISH JOURNAL OF PSYCHIATRY, 1990, 157 :34-40

[6]

BREWER C, 1986, ALCOHOL ALCOHOLISM, V21, P385

[7] DISULFIRAM TREATMENT OF ALCOHOLISM [J].

CHICK, J ;

GOUGH, K ;

FALKOWSKI, W ;

KERSHAW, P ;

HORE, B ;

MEHTA, B ;

RITSON, B ;

ROPNER, R ;

TORLEY, D .

BRITISH JOURNAL OF PSYCHIATRY, 1992, 161 :84-89

[8] ALCOHOLISM - CONTROLLED TRIAL OF TREATMENT AND ADVICE [J].

EDWARDS, G ;

ORFORD, J ;

EGERT, S ;

GUTHRIE, S ;

HAWKER, A ;

HENSMAN, C ;

MITCHESON, M ;

OPPENHEIMER, E ;

TAYLOR, C .

JOURNAL OF STUDIES ON ALCOHOL, 1977, 38 (05) :1004-1031

[9]

Gitlow SE., 1980, ALCOHOLISM PRACTICAL, P273

[10] DOSE-EFFECT RELATIONSHIP OF DISULFIRAM IN HUMAN VOLUNTEERS .2. A STUDY OF THE RELATION BETWEEN THE DISULFIRAM-ALCOHOL REACTION AND PLASMA-CONCENTRATIONS OF ACETALDEHYDE, DIETHYLDITHIOCARBAMIC ACID METHYL-ESTER, AND ERYTHROCYTE ALDEHYDE DEHYDROGENASE-ACTIVITY [J].

JOHANSSON, B ;

ANGELO, HR ;

CHRISTENSEN, JK ;

MOLLER, IW ;

RONSTED, P .

PHARMACOLOGY & TOXICOLOGY, 1991, 68 (03) :166-170