THE EPIDEMIOLOGY OF MULTIPLE-CLONE PLASMODIUM-FALCIPARUM INFECTIONS IN GAMBIAN PATIENTS

被引：110
作者：
CONWAY, DJ
GREENWOOD, BM
MCBRIDE, JS
机构：
[1] UNIV EDINBURGH, INST CELL ANIM & POPULAT BIOL, KINGS BLDG, W MAINS RD, EDINBURGH EH9 3JT, MIDLOTHIAN, SCOTLAND
[2] MRC LABS, BANJUL, SENEGAMBIA
来源：
PARASITOLOGY | 1991年 / 103卷
基金：
英国惠康基金;
关键词：
PLASMODIUM; MALARIA; GENETICS; CLONE; EPIDEMIOLOGY; IMMUNOFLUORESCENCE;
D O I：
10.1017/S0031182000059217
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
The occurrence of multiple-clone Plasmodium falciparum haploid blood-stage infections is a pre-requisite for cross-fertilization and genetic exchange at the diploid stage in the mosquito. Using monoclonal antibodies against 3 polymorphic blood-stage antigens, a method of two-colour differential immunofluorescence allowed the resolution of between 1 and 4 clones/isolate. A mean of 2 P falciparum clones was detected in the blood of malaria patients in The Gambia. The mean number of clones/patient showed no correlation with age, parasitaemia, or disease severity. There was a slight difference in mean number between sample periods, probably reflecting temporal differences in transmission intensity. A statistical analysis of 2-locus genetic diversity of clones within isolates concludes that not all multiple-clone infections result from superinfection, but that some are due to single multiple-clone inoculations.
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页码：1 / +
页数：1
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