THE KINETICS OF AMPHOTERICIN-B INTERACTION WITH THE MUSCLE-FIBER MEMBRANE

被引：0

作者：

SHVINKA, NE ^{[1
]}

CAFFIER, G ^{[1
]}

机构：

[1] CENT INST OCCUPAT PHYSIOL & MED,BERLIN,GERMANY

来源：

BIOLOGICHESKIE MEMBRANY | 1991年 / 8卷 / 12期

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D O I：

暂无

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We investigated the amphotericin B (10(-6)-10(-5) M) induced catio conductance in frog skeletal muscle fibres. The kinetics of the conductance decrease after amphotericin B was removed from the bathing solution consisted of two parts: the first with the relaxation rate constant rho = 2.03 +/- 0.21 min-1 and the slower second part depending on the amphotericin concentration. The value of rho calculated from the conductance rise was smaller than that for the conductance relaxation kinetics in the same experiment. The relaxation rate constant declined with temperature (Q10 = 2.8) and increased in prolonged experiments (greater-than-or-equal-to 80 min) after the repeated application of amphotericin B. The possible role of the nonconductive forms of amphotericin B interaction with the muscle fibre membrane is discussed.

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页码：1292 / 1303

页数：12

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