FACTORS AFFECTING METHICILLIN RESISTANCE IN STAPHYLOCOCCUS-AUREUS

被引：19
作者：
BERGERBACHI, B
机构：
[1] Institute of Medical Microbiology, University of Zürich, Postfach CH 8028 Zürich
来源：
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 1995年 / 6卷 / 01期
关键词：
STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANCE; REGULATION; GENETICS;
D O I：
10.1016/0924-8579(95)00021-Y
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Methicillin resistance in staphylococci is primarily due to the methicillin resistance determinant which produces an additional low affinity penicillin-binding protein PBP2'. Expression of PBP2' is controlled by its own regulatory element, and shares also the same induction system as beta-lactamases. However, methicillin resistance levels do not correlate with the amount of PBP2' produced, but are determined by the strain specific genetic background. These factors responsible for high methicillin resistance have not yet been characterised.
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页码：13 / 21
页数：9
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