NEUROTRANSMITTER-GATED ION CHANNELS AS UNCONVENTIONAL ALLOSTERIC PROTEINS

被引：191
作者：
GALZI, JL
CHANGEUX, JP
机构：
[1] Institut Pasteur, Neurobiologie Moléculaire, URA CNRS D1284, 75015 Paris
来源：
CURRENT OPINION IN STRUCTURAL BIOLOGY | 1994年 / 4卷 / 04期
关键词：
D O I：
10.1016/S0959-440X(94)90218-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Biochemical, mutagenesis and electron microscopy investigations of neurotransmitter receptors linked with ion channels result in a map of the neurotransmitter binding site and the ion channel at the amino acid level. The data are consistent with the view that these quasi-symmetrical hetero-oligomers are allosteric proteins, yet with distinctive features associated with their transmembrane disposition.
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页码：554 / 565
页数：12
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