NEUROTROPHIN-3 STIMULATES THE DIFFERENTIATION OF MOTONEURONS FROM AVIAN NEURAL-TUBE PROGENITOR CELLS

被引:50
作者
AVERBUCHHELLER, L
PRUGININ, M
KAHANE, N
TSOULFAS, P
PARADA, L
ROSENTHAL, A
KALCHEIM, C
机构
[1] HEBREW UNIV JERUSALEM,HADASSAH MED SCH,DEPT ANAT & EMBRYOL,POB 1172,IL-91120 JERUSALEM,ISRAEL
[2] GENENTECH INC,DEPT NEUROSCI,S SAN FRANCISCO,CA 94080
[3] NCI,FREDERICK CANC RES & DEV CTR,MOLEC EMBRYOL SECT,FREDERICK,MD 21702
关键词
AVIAN EMBRYO; SURVIVAL; TROPHIC FACTORS; TYROSINE KINASE RECEPTOR;
D O I
10.1073/pnas.91.8.3247
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Neurotrophin 3 (NT-3) promotes differentiation of neural tube progenitors into motoneurons expressing the BEN/SC1 and islet-1 epitopes. A 1.75- to 6.7-fold increase in BEN-positive motoneurons was obtained when quail neural tube cells were cultured with NT-3 at 0.1-10 ng/ml, respectively. In contrast, the overall number of cells, as well as the proportion of motoneurons that developed from cycling precursors, did not change. Addition of NT-3 at 1 ng/ml to cells obtained from ventral half-neural tubes promoted a 2.5-fold stimulation in motoneuron number, confirming the specificity of the effect. Moreover, NT-3 had no significant effect on survival of differentiated avian motoneurons. The distribution of trkC mRNA, which encodes the high-affinity receptor for NT-3, is consistent with these findings. trkC expression is homogeneous in the embryonic day 2 (E2) neural tube, becomes restricted to the mantle layer on E3, where differentiation occurs, and disappears from the ventral third of the E4-E5 spinal cord right before the onset of normal motoneuron death. These results suggest that NT-3 and trkC regulate early neurogenesis in the avian central nervous system.
引用
收藏
页码:3247 / 3251
页数:5
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