AZOLES .10. THIAZOLO[4',5' 4,5]THIENO[3,2-D]PYRIMIDINE, A NEW HETEROCYCLIC RING-SYSTEM

被引：8

作者：

ATHMANI, S

IDDON, B

机构：

[1] The Ramage Laboratories, Department of Chemistry and Applied Chemistry, University of Salford, Salford

来源：

TETRAHEDRON | 1992年 / 48卷 / 36期

关键词：

4-CHLOROTHIAZOLE-5-CARBALDEHYDES; 4-CHLOROTHIAZOLE-5-CARBONITRILES; THIENO[2,3-D]THIAZOLES; THIAZOLO[4',5 4,5]THIENO[3,2-D]PYRIMIDINES; CYTOKININ ANALOGS;

D O I：

10.1016/S0040-4020(01)90380-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Thieno[2,3-d]thiazoles were prepared by reaction of 4-chlorothiazole-5-carbaldehydes or 4-chlorothiazole-5-carbonitriles with either ethyl 2-mercaptoacetate or 2-mercaptoacetamide. The 6-aminothieno[2,3-d]thiazole-5-carboxamides obtained were converted into the corresponding thiazolo[4',5';4,5]thieno[3,2-d]pyrimidin-5(6H)-one by treatment with triethyl orthoformate in acetic anhydride. With phosphoryl chloride these gave the 5-chloro-derivative, which underwent displacement of the chlorine-atom when allowed to react with various amines. Reductive dechlorination of 5-chlorothiazolo[4',5';4,5]thieno[3,2-d]-pyrimidine gave the parent heterocycle.

引用

页码：7689 / 7702

页数：14