DIFFUSE INFANTILE HEMANGIOMATOSIS - CLINICOPATHOLOGICAL FEATURES AND MANAGEMENT PROBLEMS IN 5 FATAL CASES

被引:31
作者
BYARD, RW
BURROWS, PE
IZAKAWA, T
SILVER, MM
机构
[1] UNIV TORONTO,HOSP SICK CHILDREN,DEPT PATHOL,555 UNIV AVE,TORONTO M5G 1X8,ONTARIO,CANADA
[2] UNIV TORONTO,HOSP SICK CHILDREN,DEPT RADIOL,TORONTO M5G 1X8,ONTARIO,CANADA
[3] UNIV TORONTO,HOSP SICK CHILDREN,DEPT PAEDIAT,TORONTO M5G 1X8,ONTARIO,CANADA
关键词
NEONATAL; HEMANGIOMATOSIS; DIFFUSE; ANGIOGENIC DISEASE;
D O I
10.1007/BF01955516
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
The clinicopathological features of five fatal cases of diffuse haemangiomatosis presenting in neonatal life or early infancy are presented. The infants all had multiple skin haemangiomas as well as deep-seated lesions in many different tissues that caused protean clinical manifestations and management problems. Because the outlook may be improved by early diagnosis and application of new modes of treatment, any infant with multiple cutaneous haemangiomas should be closely assessed for possible visceral involvement. Development of hepatomegaly, high-output cardiac failure, unexplained anaemia or thrombocytopenia in these infants should immediately suggest disseminated disease. Early recognition with implementation of steroid and/or antiangiogenic therapy, embolization and/or surgery is essential to improve the chances of survival.
引用
收藏
页码:224 / 227
页数:4
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