INSULIN DIFFERENTIALLY ALTERS TRANSCAPILLARY MOVEMENT OF INTRAVASCULAR IGFBP-1, IGFBP-2 AND ENDOTHELIAL-CELL IGF-BINDING PROTEINS IN THE RAT-HEART

被引：179

作者：

BAR, RS

BOES, M

CLEMMONS, DR

BUSBY, WH

SANDRA, A

DAKE, BL

BOOTH, BA

机构：

[1] VET ADM MED CTR,DEPT ANAT,IOWA CITY,IA

[2] UNIV IOWA,DIABET & ENDOCRINOL RES CTR,IOWA CITY,IA

[3] UNIV N CAROLINA,DEPT MED,CHAPEL HILL,NC 27514

来源：

ENDOCRINOLOGY | 1990年 / 127卷 / 01期

关键词：

D O I：

10.1210/endo-127-1-497

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Insulin-like growth factor binding-proteins 1 and 2 (IGFBP-1, IGFBP-2) and endothelial cell IGF binding proteins (ECBP) were individually perfused through isolated beating rat hearts in the absence and presence of insulin. Insulin caused an increased movement of IGFBP-1 from the vascular space to tissues of the heart. Subendotheial content of IGFBP-1 was 110%, 126% (p <.01) and 132% (p < 0.05) of control hearts when perfused with 1, 10 and 100 ng/ml insulin, respectively. In contrast, insulin treatment was associated with a decrease in ECBP content in cardiac tissue, being 83%, 62% (p < 0.005) and 73%. © 1990 by The Endocrine Society.

引用

页码：497 / 499

页数：3

共 17 条

[1]

BAR BL, IN PRESS ENDOCRINOLO

[2] VASCULAR TRANSPORT OF INSULIN TO RAT CARDIAC-MUSCLE - CENTRAL ROLE OF THE CAPILLARY ENDOTHELIUM [J].