PREVENTION OF DIGITOXIN POISONING BY VARIOUS STEROIDS

被引：37

作者：

SELYE, H

JELINEK, J

KRAJNY, M

机构：

[1] Institute of Experimental Medicine and Surgery, University of Montreal, Montreal

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 09期

关键词：

Anabolic steroids–antidigitoxin activity; Androgenic steroids–antidigitoxin activity; Digitoxin poisoning–steroid effect; Spironolactone–antidigitoxin activity;

D O I：

10.1002/jps.2600580903

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Experiments on rats indicate that spironolactone as well as several anabolic androgens protect the rat against an otherwise fatal digitoxin poisoning, whereas numerous other hormonally active or inactive steroids are ineffective in this respect. Among those tested, all potent anabolic androgens possess antidigitoxin activity; however, male hormonal actions do not appear to be indispensable for this protective effect since spironolactone is devoid of anabolic and androgenic potency, yet highly active in antagonizing digitoxin. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1055 / &

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