Molecular mechanisms of resistance in epidermal growth factor receptor-mutant lung adenocarcinomas

被引：117

作者：

Cortot, Alexis B. ^{[1
,2
]}

Jaenne, Pasi A. ^{[3
]}

机构：

[1] Univ Lille Nord France, Lille Univ Hosp, Hop Calmette, Thorac Oncol Dept, Lille, France

[2] Univ Lille 1, Inst Biol Lille, UMR8161, Siric OncoLille, Lille, France

[3] Dana Farber Canc Inst, Lowe Ctr Thorac Oncol, Boston, MA 02115 USA

来源：

EUROPEAN RESPIRATORY REVIEW | 2014年 / 23卷 / 133期

关键词：

D O I：

10.1183/09059180.00004614

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The discovery of epidermal growth factor receptor (EGFR) mutations in nonsmall cell lung cancer (NSCLC) has allowed the identification of a subset of patients whose tumours are exquisitely sensitive to EGFR tyrosine kinase inhibitors (TKIs). Despite the efficacy and superiority of EGFR TKIs over chemotherapy as first-line therapy, all patients will ultimately develop progressive disease, with a median of 9-13 months progression-free survival. A better understanding of the molecular mechanisms underlying resistance to EGFR TKIs can help design new drugs and therapeutic strategies to overcome resistance. This has been illustrated by the new generation TKIs that are effective on the T790M mutation, which is the most frequent mechanism of acquired resistance to EGFR TKIs. In this article, we will address the main molecular mechanisms of primary and acquired resistance to EGFR TKIs in EGFR-mutant NSCLC.

引用

页码：356 / 366

页数：11

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