LONG-TERM PRODUCTION OF ERGOT PEPTIDES BY IMMOBILIZED CLAVICEPS-PURPUREA IN SEMICONTINUOUS AND CONTINUOUS-CULTURE

被引：9

作者：

DIERKES, W ^{[1
]}

LOHMEYER, M ^{[1
]}

REHM, HJ ^{[1
]}

机构：

[1] UNIV MUNSTER,INST MIKROBIOL,CORRENSSTR 3,W-4400 MUNSTER,GERMANY

来源：

APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 1993年 / 59卷 / 07期

关键词：

D O I：

10.1128/AEM.59.7.2029-2033.1993

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The semicontinuous and continuous production of pharmaceutically useful ergot peptides with immobilized Claviceps purpurea could be demonstrated. A key aspect was the presence of high concentrations of CaCl2 (96.9 mM) to give marked prolongation of the productive phase, and cultivation in a bubble column reactor became possible. Restriction of the phosphate supply avoided an otherwise problematic massive increase of outgrowing hyphae.

引用

页码：2029 / 2033

页数：5

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