HEREDITARY CEREBRAL-HEMORRHAGE WITH AMYLOIDOSIS - DUTCH TYPE - ITS IMPORTANCE FOR ALZHEIMER RESEARCH

被引：45

作者：

HAAN, J ^{[1
]}

HARDY, JA ^{[1
]}

ROOS, RAC ^{[1
]}

机构：

[1] UNIV LONDON,ST MARYS HOSP,SCH MED,DEPT BIOCHEM,LONDON W2 1PG,ENGLAND

来源：

TRENDS IN NEUROSCIENCES | 1991年 / 14卷 / 06期

关键词：

D O I：

10.1016/0166-2236(91)90120-J

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alzheimer's disease is now commonly regarded as a form of 'amyloid encephalopathy' 1-6. Amyloid deposits in the cerebral blood vessels and parenchyma consist mainly of a unique protein called amyloid-beta protein (A-beta-P), which has a molecular weight of 4 kDa and is 42 amino acids long. These deposits are thought to be of pathogenetic importance in Alzheimer's disease. Recently, therefore, attention has been focused on the process of turnover of the precursorof A-beta-P to amyloid fibrils, and the deposition and persistence of A-beta-P in this disease. The study of several other diseases with cerebral A-beta-P deposition can be informative in this respect, because they allow the comparison of different pathogenetic mechanisms that lead to this type of deposition. One of these diseases is hereditary cerebral hemorrhage with amyloidosis - Dutch type (HCHWA-D), which is the subject of this review.

引用

页码：231 / 234

页数：4

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