Microwave assisted synthesis of 2'-/3'-azaflavones/azaflavonones and their N-alkyl derivatives

被引：0

作者：

Yasar, Ahmet ^{[1
]}

Ulas, Nevin ^{[1
]}

Yildirim, Sercan ^{[1
]}

机构：

[1] Karadeniz Tech Univ, Fac Pharm, TR-61080 Trabzon, Turkey

来源：

ORGANIC COMMUNICATIONS | 2016年 / 9卷 / 04期

关键词：

Azaflavone; azaflavonone; microwave; azachalcone;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2'-Azaflavonone (6) and 3'-azaflavonone (7); were synthesized by a simple environmentally friendly microwave-assisted one-pot method for the cyclization of 2'-hydroxy beta'-2-azachalcanon-beta-ol (1), 2'-hydroxy (E)-2-azachalcone (2), 2'-hydroxy (E)-3-azachalcone (3) under solventless conditions using K-10 clay. In addition to these synthesis, 3-(pyridin-2-yl methyl)-2'-azaflavone (8) and 3-(pyridin-3-yl methyl)-3'-azaflavone (9) were synthesized using silica-supported sodium hydrogen sulphate then the treatment with base, respectively. Additionally, for antimicrobial activities N-alkyl substituted 3'-azaflavonium and 2'-azaflavonium bromides (1012) were prepared from compounds 3, 4 -5 and 8 -9.

引用

页码：73 / 81

页数：9

共 18 条

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